Combination of immunotherapy with local chemotherapy for the treatment of malignancies
AssigneeThe Johns Hopkins University
InventorsDIMITRIOS MATHIOS, BETTY TYLER, DREW PARDOLL, HENRY BREM, MICHAEL LIM
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Abstract
The presently disclosed subject matter provides methods, compositions, and kits for the treatment of cancer using a combination treatment comprising a locally administered chemotherapy and an immunotherapeutic agent. The presently disclosed subject matter also provides methods of promoting the combination treatment and instructing a patient to receive the combination treatment are also provided, as well immunotherapeutic, non-immunosuppressive compositions comprising the combination treatment, and methods of using the immunotherapeutic, non-immunosuppressive compositions for treating cancer.
Claims22
A method for the treatment of cancer comprising administering to a patient with a cancer an effective amount of a combination treatment comprising:
- (a) a locally administered chemotherapy;
- and
- (b) an immunotherapeutic agent.
An immunotherapeutic, non-immunosuppressive composition comprising:
- (a) a locally administered chemotherapy;
- and
- (b) an immunotherapeutic agent.
A kit comprising:
- (a) a locally administered chemotherapy;
- (b) an immunotherapeutic agent;
- and
- (c) a package insert or label with directions to treat a patient with a cancer by administering a combination treatment comprising the locally administered chemotherapy and the immunotherapeutic agent.
Dependencies are inferred from the claim text.