Pharmaceutical composition comprising ubiquinone-5 and method of use thereof
AssigneeThe Trustees of Columbia University in the City of New York
InventorRichard J. LEVY
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Abstract
The present disclosure provides for a pharmaceutical composition comprising ubiquinone-5 (UB5) and method of use thereof. The present disclosure relates to ubiquinone-5 used as an anesthetic, sedative agent, hypnotic agent, or combination thereof.
Claims20
A pharmaceutical composition comprising a ubiquinone-5 containing oil-in-water emulsion.
The composition as in any preceding claim, wherein the ubiquinone-5 is dissolved in a water-immiscible solvent.
The composition as in any preceding claim, wherein the ubiquinone-5 is emulsified with water.
The composition as in any preceding claim, further comprising, an excipient selected from the group consisting of amino acids, vitamins, minerals, and a combination thereof.
The composition as in any preceding claim, wherein the ubiquinone-5 is present in an amount from about 0.01% (w/v) to 5% (w/v).
The composition as in any preceding claim, wherein the pH of the composition ranges from about 5.0 to about 8.0.
The composition as in any preceding claim, further comprising a tonicity modifier.
The composition as in any preceding claim, further comprising ascorbic acid or its pharmaceutically acceptable salt thereof.
The composition as in any preceding claim, wherein the composition is for administration by a route selected from the group consisting of intravenous, inhalational, subcutaneous, intramuscular, transdermal, and parenteral administration.
The composition as in any preceding claim, wherein the composition further comprises decylubiquinone.
A method of inducing anesthesia in a subject, comprising administering to the subject an effective amount of a composition comprising a ubiquinone-5 containing oil-in-water emulsion.
A process for preparing a pharmaceutical composition of ubiquinone-5 for parenteral administration, the process comprising:
- a. dispersing at least one surfactant;
- b. dissolving ubiquinone-5 in at least one water-immiscible solvent to form a non-aqueous ubiquinone-5 solution;
- and
- c. adding the non-aqueous ubiquinone-5 solution to the surfactant dispersion to form a crude oil-in-water emulsion of ubiquinone-5.
Dependencies are inferred from the claim text.