Use of tapinarof for the treatment of atopic dermatitis
AssigneeDermavant Sciences GmbH
InventorsJohn E. KRAUS, James LEE
Life of this patent
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Abstract
Topical compositions and methods for using topical compositions comprising tapinarof to treat mild to moderate atopic dermatitis or plaque psoriasis are described herein. Also described are clinical endpoints for treatment of subjects diagnosed with mild to moderate atopic dermatitis, wherein about 5% to about 35% of body surface area was affected, and Investigator Global Assessment (IGA) score was greater than or equal to 3. Also described are clinical endpoints for treatment of subjects diagnosed with chronic mild to moderate plaque psoriasis for greater than or equal to 6 months, wherein about 3% to about 20% of body surface area was affected, and Physician Global Assessment (PGA) score was greater than or equal to 2.
Claims29
A method for treating mild to severe atopic dermatitis in a subject comprising topically administering a topical composition containing about 1.0% tapinarof to affected areas of the subject once a day, wherein after topically administering the topical composition an Investigator Global Assessment (IGA) score is improved by 2 grades.
A method for treating mild to severe atopic dermatitis in a subject comprising topically administering a topical composition containing about 1.0% tapinarof to affected areas of the subject once a day, wherein after topically administering the topical composition an Investigator Global Assessment (IGA) score has improved to a score of 0 or 1.
Dependencies are inferred from the claim text.