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AssigneeShanghai Bocimed Pharmaceutical Co., Ltd.
InventorsShuhuan YING, Zhixiang CHEN, Xian ZHANG, Tao ZHU, Tingting WANG
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A pharmaceutical composition containing cariprazine, a preparation method and an application thereof are provided. The pharmaceutical composition contains cariprazine pamoate solid particles. A particle size of the cariprazine solid particles has a Dv(10) less than or equal to 30 microns, a Dv(50) less than or equal to 50 microns, and a Dv(90) less than or equal to 100 microns. When being used, the pharmaceutical composition containing cariprazine is an aqueous suspension and, the concentration of the free base of cariprazine is moderate. A long-term effect can be achieved upon injection of a certain administration volume of the pharmaceutical composition, thereby reducing the frequency of medication while increasing patient medication compliance. Furthermore, the pharmaceutical composition has a high bioavailability and has promising marketing prospects.
A pharmaceutical composition of cariprazine, wherein the pharmaceutical composition of cariprazine comprises solid particles of cariprazine, wherein the solid particles of cariprazine have particle sizes Dv(10) of ≤30 microns, Dv(50) of ≤50 microns and Dv(90) of ≤100 microns, preferably ≤10 microns;
Dependencies are inferred from the claim text.