Osteoinductive implants and related manufacturing methods
AssigneeSpectrum Spine IP Holdings, LLC
InventorsJames C. Robinson, Timothy Ganey
Life of this patent
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Abstract
An implant device configured to be at least partially in contact with bone on implantation and having an improved osteoinductive feature to enhance new bone formation. The implant device has one or more bone growth surfaces extending from a structurally solid feature of the implant device. The one or more bone growth surfaces are configured to mimic adult trabecular bone by having recesses and prominences. The recesses extend 10 to 500 microns in depth and may have an increasing inclination from the surface extending inwardly and not parallel to opposing or adjacent walls. The one or more bone growth surfaces form a random and/or non-random network.
Claims20
A method of manufacturing an implant device configured to have at least one osteoinductive feature to enhance new bone formation after implantation, the method comprising:
- providing an implant device;
- laser etching one or more surfaces of the implant device to create a plurality of recesses extending into the implant device;
- wherein each recess has a mouth, an end opposite from the mouth, and a sidewall extending between the mouth and the end and into the implant device;
- wherein the recesses are shaped as directed by a non-random, engineered pattern;
- and
- wherein the mouth of each recess has a width, and most of the mouths have a width within a range of about 100 nm to about 2 mm;
- and
- laser treating surfaces of the implant device including surfaces of the sidewalls of the recesses and surfaces around the mouth of each recess to create surface deformations that are random in comparison to the pattern of the recesses and are significantly smaller than the width of the recesses.
A method of manufacturing an implant device configured to have at least one osteoinductive feature to enhance new bone formation after implantation, the method comprising:
- providing an implant device with one or more surfaces that have a plurality of recesses extending into the implant device;
- wherein each recess has a mouth, an end opposite from the mouth, and a sidewall extending between the mouth and the end and into the implant device;
- wherein the recesses are arranged in a non-random, engineered pattern;
- and
- wherein each recess has a depth, and most of the recesses have a width within a range of about 1 micron to about 2 mm;
- and
- laser treating surfaces of the implant device including surfaces of the sidewalls of the recesses and surfaces around the mouth of each recess to create surface deformations that are random in comparison to the pattern of the recesses and are significantly smaller than the width of the recesses;
- wherein most of the surface deformations, as seen under high magnification, have a length or width of less than 200 nanometers.
An implant device configured having at least one osteoinductive feature to enhance new bone formation after implantation, the implant device comprising:
- one or more surfaces of the implant device having a plurality of recesses extending into the implant device;
- wherein each recess has a mouth, an end opposite from the mouth, and a sidewall extending between the mouth and the end;
- wherein the sidewall extends inwardly from the mouth to the end and has a mid-depth halfway between the mouth and the end;
- wherein each recess has a depth as measured from its mouth to its end, and at least a majority of the recesses have a depth within a range from about 10 to about 500 microns;
- and
- wherein at least a majority of the recesses are structured to narrow progressively inward because the sidewall of the recess that is structured to narrow progressively inward, is inclined from its mouth to its end or at least to its mid-depth.
Dependencies are inferred from the claim text.