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US 2023/0413823 A1Published application
Hyperloaded yeast cell wall particle and uses thereof
AssigneeUniversity of Massachusetts
InventorsGary R. Ostroff, Ernesto R. Soto, Florentina Rus
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Abstract
The present disclosure provides hyperloaded yeast particles. The disclosure further provides methods of making hyperloaded yeast particles and methods of using hyperloaded yeast particles.
Claims29
A hyperloaded yeast particle (YP) comprising a YP and a hydrophobic payload, wherein:
- the hydrophobic payload is present within the YP;
- the weight by weight (w/w) ratio of the hydrophobic payload:the hyperloaded YP is between about 2:1 and about 5:1;
- and
- the hydrophobic payload is releasable from the hyperloaded YP upon contact with an aqueous solution.
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A method of preparing a hyperloaded yeast particle (YP) comprising the steps of:
- a. hydrating a YP with at least 0.5 μL aqueous solution per milligram of YP;
- and
- b. incubating the hydrated YP with a hydrophobic payload to encapsulate the hydrophobic payload within the YP.
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Dependencies are inferred from the claim text.