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US 2023/0408532 A1Published application
Erythrocyte-derived extracellular vesicles and proteins associated with such vesicles as biomarkers for parkinson's disease
AssigneeUniversite Laval
InventorsFrancesca Cicchetti, Eric Boilard
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Abstract
The present description relates to methods for clinically assessing Parkinson's disease in a subject using protein biomarkers of erythrocyte-derived extracellular vesicles (EEV).
Claims13
-44. (canceled)
An in vitro method for preparing a clinical human blood sample, the method comprising
- (a) obtaining a preparation of isolated erythrocyte-derived extracellular vesicles (EEV) from a blood sample of a subject having or suspected of having Parkinson's disease;
- (b) processing the preparation of isolated EEV by separating extracellular vesicles having a diameter of greater than 100 nm from extracellular vesicles having a diameter of less than 100 nm, thereby obtaining a processed blood sample enriched for extracellular vesicles having a diameter of greater than 100 nm;
- and
- (c) quantifying the expression levels of one or more protein biomarkers in the processed blood sample of (b).
1 more element
An in vitro method for preparing a clinical human blood sample, the method comprising
- (a) receiving a preparation of isolated erythrocyte-derived extracellular vesicles (EEV) enriched for EEV having a diameter of greater than 100 nm, from a blood sample of a subject having or suspected of having Parkinson's disease;
- and
- (b) quantifying the expression levels of one or more protein biomarkers, in the preparation of isolated EEV enriched for EEV having a diameter of greater than 100 nm.
Dependencies are inferred from the claim text.