# US 2023/0408433 A1 · Combined transfer module with integrated conductivity measurement

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- Number: US 2023/0408433 A1
- Document ID: US20230408433A1
- Status: Published application
- Kind: A1
- Application number: 18/035,717
- Filed: 2021-11-05
- Published: 2023-12-21
- Earliest claimed: 2020-11-06
- Assignees: Bl Technologies, Inc.
- Applicants: BL Technologies, Inc.
- Inventors: Paul Kosenka; Krzysztof Franaszczuk; Bryan Schiffner; Paulus VanHoudt; Helen Prieto; Josh Engel
- Web page: https://patentgrep.com/patent/US20230408433A1

## CPC

- G01N 27/07: Construction of measuring vessels; Electrodes therefor
- G01N 33/1846: {Total carbon analysis}
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)

## Abstract

A device for analyzing total organic carbon (TOC) within a fluid at a desired temperature can include one or more transfer modules, each including a first and second transfer plate. A first fluid channel is formed in the first transfer plate and a second fluid channel is formed in the second transfer plate. A CO2 permeable membrane is disposed between the first fluid channel and the second fluid channel and a temperature measurement device measures a temperature of a fluid within the first and/or second fluid channel. A temperature control system is configured to heat or cool the transfer plates. Heating or cooling the transfer plates heats or cools the fluid within the first and/or second fluid channel to the desired temperature. One or more conductivity sensors are configured to measure a conductivity of the fluid within the first and/or second fluid channel.

## Claims

### Claim 1

A device for measuring conductivity of a fluid at a desired temperature, the device comprising:
one or more transfer modules, each transfer module comprising:
a first transfer plate, the first transfer plate having a first side and a second side, wherein a first fluid channel is formed in the first side of the first transfer plate;
a second transfer plate, the second transfer plate having a first side and a second side, wherein a second fluid channel is formed in the first side of the second transfer plate, wherein the first side of the first transfer plate faces the first side of the second transfer plate; and
a gas permeable membrane disposed between the first transfer plate and the second transfer plate, wherein a portion of the first fluid channel and a portion of the second fluid channel are separated by the gas permeable membrane;
one or more temperature measurement devices configured to measure a temperature of a fluid in at least one of the first fluid channel or the second fluid channel;
a temperature control system configured to heat or cool at least one of the first transfer plate and the second transfer plate of each of the one or more transfer modules, wherein heating or cooling the at least one of the first transfer plate and the second transfer plate causes the fluid to be heated or cooled to the desired temperature; and
one or more conductivity sensors configured to measure i) a conductivity of the fluid within the portion of the first fluid channel separated from the second fluid channel by the gas permeable membrane at the desired temperature and/or ii) a conductivity of the fluid within the portion of the second fluid channel separated from the first fluid channel by the gas permeable membrane at the desired temperature.

### Claim 2 (depends on 1)

The device of claim 1, wherein, for each transfer module, the second side of the first transfer plate is attached to a first clamp plate and the second side of the second transfer plate is attached to a second clamp plate.

### Claim 3 (depends on 2)

The device of claim 2, the temperature control system further configured to heat or cool at least one of the first clamp plate and the second clamp plate.

### Claim 4 (depends on 1)

The device of claim 1, the temperature control system comprising one or more solid state heat pumps cooled by a heatsink.

### Claim 5 (depends on 1)

The device of claim 1, wherein the fluid in at least one of the first fluid channel or the second fluid channel comprises at least a portion of a fluid sample.

### Claim 6 (depends on 1)

The device of claim 1, wherein i) the conductivity of the fluid within the portion of the first fluid channel separated from the second fluid channel by the gas permeable membrane measured at the desired temperature and/or ii) the conductivity of the fluid within the portion of the second fluid channel separated from the first fluid channel by the gas permeable membrane measured at the desired temperature are used to determine total organic carbon (TOC) of the fluid.

### Claim 7 (depends on 1)

The device of claim 1, each transfer module further comprising a third fluid channel containing an unaltered portion of the fluid, wherein:
the temperature control system changes the temperature of the unaltered portion of the fluid sample to the desired temperature, and
the one or more conductivity sensors measure a conductivity of the unaltered portion of the fluid sample at the desired temperature.

### Claim 8 (depends on 1)

The device of claim 1, wherein the gas permeable membrane is a CO2 permeable membrane.

### Claim 9

A method for analyzing total organic carbon (TOC) within a fluid at a desired temperature, the method comprising:
providing one or more transfer modules, each transfer module comprising:
a first transfer plate, the first transfer plate having a first side and a second side, wherein a first fluid channel is formed in the first side of the first transfer plate;
a second transfer plate, the second transfer plate having a first side and a second side, wherein a second fluid channel is formed in the first side of the second transfer plate, wherein the first side of the first transfer plate faces the first side of the second transfer plate; and
a CO2 permeable membrane disposed between the first transfer plate and the second transfer plate, wherein a portion of the first fluid channel and a portion of the second fluid channel are separated by the CO2 permeable membrane;
measuring a temperature of the fluid within at least one of the first fluid channel or the second fluid channel using one or more temperature measurement devices;
heating or cooling at least one of the fluid within the first fluid channel or the fluid within the second fluid channel to the desired temperature using a temperature control system, the temperature control system configured to heat or cool at least one of the first transfer plate and the second transfer plate of each transfer module to affect a temperature of at least one of the fluid within the first fluid channel or the fluid within the second fluid channel; and
measuring i) a conductivity of the fluid within the portion of the first fluid channel separated from the second fluid channel by the CO2 permeable membrane and/or ii) a conductivity of the fluid within the portion of the second fluid channel separated from the first fluid channel by the CO2 permeable membrane using one or more conductivity sensors.

### Claim 10 (depends on 9)

The method of claim 9, wherein, for each transfer module, the second side of the first transfer plate is attached to a first clamp plate and the second side of the second transfer plate is attached to a second clamp plate.

### Claim 11 (depends on 10)

The method of claim 10, the temperature control system further configured to heat or cool at least one of the first clamp plate and the second clamp plate.

### Claim 12 (depends on 9)

The method of claim 9, wherein i) the conductivity of the fluid within the portion of the first fluid channel separated from the second fluid channel by the CO2 permeable membrane measured at the desired temperature and/or ii) the conductivity of the fluid within the portion of the second fluid channel separated from the first fluid channel by the CO2 permeable membrane measured at the desired temperature are used to determine total organic carbon (TOC) of the fluid sample.

### Claim 13 (depends on 9)

The method of claim 9, each transfer module further comprising a third fluid channel containing an unaltered portion of the fluid, wherein:
the temperature control system changes the temperature of the unaltered portion of the fluid sample to the desired temperature, and
the one or more conductivity sensors measure a conductivity of the unaltered portion of the fluid sample at the desired temperature.

### Claim 14 (depends on 9)

The method of claim 9, the temperature control system comprising one or more solid state heat pumps cooled by a heatsink.

### Claim 15

A system for analyzing total organic carbon (TOC) within a fluid at a desired temperature, the system comprising:
one or more transfer modules, each transfer module comprising:
a first transfer plate, the first transfer plate having a first side and a second side, wherein a first fluid channel is formed in the first side of the first transfer plate;
a second transfer plate, the second transfer plate having a first side and a second side, wherein a second fluid channel is formed in the first side of the second transfer plate, wherein the first side of the first transfer plate faces the first side of the second transfer plate; and
a gas permeable membrane disposed between the first transfer plate and the second transfer plate, wherein a portion of the first fluid channel and a portion of the second fluid channel are separated by the gas permeable membrane;
one or more temperature measurement devices configured to measure a temperature of a fluid within the first fluid channel and/or a temperature of a fluid within the second fluid channel;
a temperature control system configured to heat or cool at least one or both of the first transfer plate and the second transfer plate of each of the one or more transfer modules, wherein heating or cooling the at least one or both of the first transfer plate and the second transfer plate heats or cools the fluid within the first fluid channel and/or the fluid within the second fluid channel to the desired temperature; and
one or more conductivity sensors configured to measure a conductivity of the fluid within the portion of the first fluid channel separated from the second fluid channel by the gas permeable membrane and/or a conductivity of the fluid within the portion of the second fluid channel separated from the first fluid channel by the gas permeable membrane.

### Claim 16 (depends on 15)

The system of claim 15, wherein, for each transfer module, the second side of the first transfer plate is attached to a first clamp plate and the second side of the second transfer plate is attached to a second clamp plate.

### Claim 17 (depends on 16)

The system of claim 16, the temperature control system further configured to heat or cool at least one of the first clamp plate and the second clamp plate.

### Claim 18 (depends on 15)

The system of claim 15, the temperature control system comprising one or more solid state heat pumps cooled by a heatsink.

### Claim 19 (depends on 15)

The system of claim 15, wherein i) the conductivity of the fluid within the portion of the first fluid channel separated from the second fluid channel by the gas permeable membrane measured at the desired temperature and/or ii) the conductivity of the fluid within the portion of the second fluid channel separated from the first fluid channel by the gas permeable membrane measured at the desired temperature are used to determine total organic carbon (TOC) of the fluid sample.

### Claim 20 (depends on 15)

The system of claim 15, wherein the gas permeable membrane is a CO2 permeable membrane.
