Cleavable disulfide linkers and uses thereof

A compound having the formula:

• wherein
• B is a divalent nucleobase;
• R1 is a polyphosphate moiety, 5′-nucleoside protecting group, monophosphate moiety, or nucleic acid moiety;
• R2 is hydrogen or —OH;
• R3 is a reversible terminator moiety, hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R4 is a detectable moiety;
• L100 is a divalent linker comprising
• wherein
• R5 and R6 are independently unsubstituted alkyl, —CN, —OH, —NH2, —COOH, —CONH2, —NO2, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, substituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• and
• W1 and W2 are —O—.