Switchable nucleic acid-scaffolded catalytic systems and method of use

Abstract

The present disclosure relates to nucleic acid-scaffolded catalytic systems. In one embodiment, a nucleic acid-scaffolded catalytic system may include a nucleic acid catalyst composed of a first nucleic acid strand and, optionally, a second nucleic acid strand. The nucleic acid catalyst may further include a first reactive moiety attached to the first nucleic acid strand, and a second moiety attached to the first nucleic acid strand or the second nucleic acid strand. A catalytic activity of the first reactive moiety may be dependent on a distance between the first reactive moiety and the second moiety. The system may further include an analyte that binds to the nucleic acid catalyst to trigger a switch in the catalytic activity of the first reactive moiety by altering the distance between the first reactive moiety and the second moiety.

Dependencies are inferred from the claim text.