Inducible pluripotent stem cell derived regenerative t cells
AssigneeCreative Medical Technologies, Inc.
InventorsThomas ICHIM, Amit PATEL, Courtney BARTLETT
Life of this patent
Estimating the term…
Abstract
Disclosed are novel cellular compositions of matter and treatment means for generation of universal donor regenerative T cells by exposure to mesenchymal stem cells or supernatant derived thereof. In one embodiment, regenerative T cells are created by differentiation of pluripotent stem cells in the presence of supernatant generated from activated mesenchymal stem cell population. The invention provides for creation of T cells which are capable of endowing regenerative activity, and/or anti-inflammatory, and/or angiogenic activity.
Claims20
A method for production of T cells possessing ability to regenerate injured tissue comprising the steps of:
- a) obtaining a pluripotent stem cell;
- b) differentiating said pluripotent stem cell into a T cell;
- c) contacting said pluripotent stem cell at one or more time points during the differentiation process with mesenchymal stem cells or products derived thereof;
- and d) isolating T cells possessing regenerative activity.
Dependencies are inferred from the claim text.