Stabilized formulations containing anti-pcsk9 antibodies

A method for preparing a composition that comprises an anti-PCSK9 antibody and less than 0.3% water, the method comprising the steps of:

• a) in a glass vial combining water, an anti-PCSK9 antibody, histidine, sucrose, and polysorbate 20;
• b) holding the combination of step (a) at about 5° C. for about 60 minutes;
• then
• c) decreasing the temperature at a rate of about 0.5° C. per minute;
• then
• d) holding at about −45° C. for about 120 minutes;
• then
• e) reducing the atmosphere pressure to about 100 mTorr;
• f) increasing the temperature at a rate of about 0.5° C. per minute;
• then
• g) holding at about −25° C. for about 78 hours;
• then
• h) increasing the temperature at a rate of 0.2° C. per minute;
• then
• i) holding at about 35° C. for about 6 hours;
• then
• j) decreasing the temperature at a rate of about 0.5° C.;
• then
• k) holding at about 250 for about 60 minutes, prior to storage.