Methods and compositions relating to anti-chi3l1 antibody reagents
AssigneeBrown University
InventorsJack A. Elias, Chun Geun Lee, Chuan Hua He, Bing Ma, Suchitra Kamle, Chang-Min Lee
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Abstract
Described herein are methods and compositions relating to anti-Chi3L1 antibodies, antibody reagents, and antigen-binding fragments thereof which display superior properties, e.g., high sensitivity, high specificity, high binding affinity, neutralization activity ex vivo and in vivo (e.g., blocks Chi3L1-induced MAPK and AKT signaling). Methods of treatment, e.g., of treating cancer, obesity, and/or asthma by administering the compounds described herein are also provided.
Claims21
1-30. (canceled)
A method of treating obesity or preventing weight gain in a subject in need thereof, the method comprising administering, to the subject, an immunoglobulin antibody that specifically binds an CHI3L1 polypeptide, said immunoglobulin antibody comprising complementarity determining regions (CDRs) of:
- a. a light chain CDR1 having the amino acid sequence of SEQ ID NO:
- 4;
- b. a light chain CDR2 having the amino acid sequence of SEQ ID NO:
- 5;
- c. a light chain CDR3 having the amino acid sequence of SEQ ID NO:
- 6;
- d. a heavy chain CDR1 having the amino acid sequence of SEQ ID NO:
- 1;
- e. a heavy chain CDR2 having the amino acid sequence of SEQ ID NO:
- 2;
- and
- f. a heavy chain CDR3 having the amino acid sequence of SEQ ID NO:
- 3.
A method of promoting weight or fat loss in a subject in need thereof, the method comprising administering, to the subject, an immunoglobulin antibody that specifically binds an CHI3L1 polypeptide, said immunoglobulin antibody comprising complementarity determining regions (CDRs) of:
- a. a light chain CDR1 having the amino acid sequence of SEQ ID NO:
- 4;
- b. a light chain CDR2 having the amino acid sequence of SEQ ID NO:
- 5;
- c. a light chain CDR3 having the amino acid sequence of SEQ ID NO:
- 6;
- d. a heavy chain CDR1 having the amino acid sequence of SEQ ID NO:
- 1;
- e. a heavy chain CDR2 having the amino acid sequence of SEQ ID NO:
- 2;
- and
- f. a heavy chain CDR3 having the amino acid sequence of SEQ ID NO:
- 3.
Dependencies are inferred from the claim text.