Use of anti-trem1 neutralizing antibodies for the treatment of motor neuron neurodegenerative disorders
AssigneeUcb Biopharma Srl
InventorsIrena KADIU, Julien GASSER, James Martin KEANEY, Anastasios SPILIOTOPOULOS, Jonathan Mark PHILLIPS
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Abstract
The present invention provides antibodies or antigen-binding fragment thereof that bind and neutralize TREM1 for use in the treatment of a motor neuron degenerative disorders, in particular amyotrophic lateral sclerosis.
Claims21
A method of treating a motor neuron degenerative disorder in a subject in need thereof, the method comprising systemically administering to the subject an antibody or antigen-binding fragment thereof that binds and neutralizes TREM1.
An antibody or antigen-binding fragment thereof that binds and neutralizes TREM1 for use in the treatment of a motor neuron degenerative disorder, wherein said antibody or antigen-binding fragment thereof is administered systemically.
Use of an antibody or antigen-binding fragment thereof that binds and neutralizes TREM1 for the manufacture of a medicament for systemic administration for the treatment of a motor neuron degenerative disorder.
An in vitro or ex vivo method of inhibiting phagocytic ability of microglia and/or migratory capacity of microglia, the method comprising contacting and incubating microglia cells with an antibody or antigen-binding fragment thereof that binds and neutralizes TREM1.
Dependencies are inferred from the claim text.