Serpin peptides and methods of using the same
AssigneeSerpin Pharma, LLC
InventorsDana AUSTIN, Cohava GELBER
Life of this patent
Estimating the term…
Abstract
Disclosed herein are SERPIN peptides, and analogues and derivatives thereof, and uses of the same for treating various conditions associated with LRP1 or TSLP.
Claims30
A method of reducing inflammation in a subject having a disease or condition associated with LRP1 or TSLP, comprising administering a SERPIN peptide comprising an amino acid sequence selected from the group consisting of VKFNKPFVFLMIEQNTK (SEQ ID NO:
- 2), VKFNKPFVFLM (SEQ ID NO:
- 25), LRFNRPFLVVI (SEQ ID NO:
- 29), VRFNRPFLMII (SEQ ID NO:
- 31), VKFNKPFVFL(NIe) (SEQ ID NO:
- 40), RFNRPFLVVIR (SEQ ID NO:
- 41), RFNRPFLMIIR (SEQ ID NO:
- 42), RFNKPFVFL(NIe)R (SEQ ID NO:
- 43), RRRFLVVIRRR (SEQ ID NO:
- 44), RRRFLMIIRRR (SEQ ID NO:
- 45), RRRFVFL(NIe)RRR (SEQ ID NO:
- 46), FVFLM (SEQ ID NO:
- 3), and FVFL(NIe) (SEQ ID NO:
- 10) to the subject to reduce inflammation associated with the disease or condition associated with LRP1 or TSLP.
2-7. (canceled)
(canceled)
14-21. (canceled)
24-25. (canceled)
28-60. (canceled)
A method of treating a subject having a disease or condition associated with LRP1, comprising administering a SERPIN peptide comprising an amino acid sequence of VKFNKPFVFL(NIe)IEQNTK (SEQ ID NO:
- 35) to the subject to treat the disease or condition associated with LRP1, wherein the disease or condition is acute or neuropathic pain, nociceptive pain, or inflammatory pain.
62-71. (canceled)
77-92. (canceled)
A method of treating a subject having a disease or condition associated with LRP1 or TSLP, comprising administering a SERPIN peptide comprising an amino acid sequence selected from the group consisting of VKFNKPFVFL(NIe)IEQNTK (SEQ ID NO:
- 35) to the subject to treat the disease or condition associated with LRP1 or TSLP, wherein the disease or condition is caused by A. alternata.
94-103. (canceled)
105-108. (canceled)
111-128. (canceled)
Dependencies are inferred from the claim text.