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US 2023/0406855 A1Published application
N-1 branched imidazoquinolines, conjugates thereof, and methods
Assignee3M Innovative Properties Company
InventorsGeorge W. Griesgraber, Mark A. Tomai, Hannah C. Cohen, Devon M. Hunerdosse
Life of this patent
Estimating the term…
Abstract
Imidazoquinoline compounds, salts thereof, conjugates thereof, pharmaceutical compositions containing the compounds and conjugates, and methods of use of such compounds as immune response modifiers, for inducing cytokine biosynthesis in humans and animals.
Claims20
A compound of Formula (I), or salt thereof:
- wherein:
- n is an integer of 0 or 1;
- R is selected from the group consisting of halogen, hydroxyl, alkyl, alkoxy, and —C(O)—O-alkyl;
- R1 is —(C1-C3)alkylene-O—(C1-C3)alkyl;
- and
- R2 is a —(C1-C18)alkylene group or —(C2-C18)alkenylene group, optionally including one or more catenary non-peroxidic —O— atoms.
3 more elements
A compound of Formula (II), or salt thereof:
- wherein:
- n is an integer of 0 or 1;
- R is selected from the group consisting of halogen, hydroxyl, alkyl, alkoxy, and —C(O)—O-alkyl;
- R1 is —(C1-C3)alkylene-O—(C1-C3)alkyl;
- R2 is a —(C1-C18)alkylene group or —(C2-C18)alkenylene group, optionally including one or more catenary non-peroxidic —O— atoms;
- and
- R3 is selected from the group consisting of alkyl, aryl, and aralkyl, wherein:
- the alkyl or alkyl portion of the aralkyl optionally includes one or more catenary non-peroxidic —O— atoms;
- the alkyl or alkyl portion of the aralkyl optionally is terminated with a functional group selected from the group consisting of amine (—NH2), carboxyl (—C(O)OH), hydroxyl (—OH), and thiol (—SH);
- and
- the aryl or aryl portion of the aralkyl is optionally substituted with halogen, hydroxyl, alkyl, alkoxy, or combinations thereof.
8 more elements
A compound of Formula (III), or salt thereof:
- wherein:
- n is an integer of 0 or 1;
- R is selected from the group consisting of halogen, hydroxyl, alkyl, alkoxy, and —C(O)—O-alkyl;
- R1 is —(C1-C3)alkylene-O—(C1-C3)alkyl;
- R2 is a —(C1-C18)alkylene group or —(C2-C18)alkenylene group, optionally including one or more catenary non-peroxidic —O— atoms;
- and
- Linker is a crosslinking group;
- m is an integer of 0 or 1;
- Q is a functional group for bonding to a polymeric moiety or second active moiety.
6 more elements
An IRM-containing conjugate of Formula (IV), or salt thereof:
- wherein:
- n is an integer of 0 or 1;
- R is selected from the group consisting of halogen, hydroxyl, alkyl, alkoxy, and —C(O)—O-alkyl;
- R1 is —(C1-C3)alkylene-O—(C1-C3)alkyl;
- R2 is a —(C1-C18)alkylene group or —(C2-C18)alkenylene group, optionally including one or more catenary non-peroxidic —O— atoms;
- Linker is a crosslinking group;
- m is an integer of 0 or 1;
- Z is a polymeric moiety or second active moiety;
- and
- the -Linkerm-Z portion of the conjugate, with or without a linker, optionally includes a labile bond.
7 more elements
Dependencies are inferred from the claim text.