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US 2023/0406845 A1Published application
Novel potassium channel inhibitors
AssigneeACESION PHARMA ApS
InventorsAntonio METE, Ulrik SØRENSEN
Life of this patent
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Abstract
A compound of the general formula (I), and the pharmaceutical composition including a compound of formula (I) and optionally a pharmaceutically acceptable additive. Also, the treatment of a cardiac disease, disorder or condition in a mammal, which includes the administration to the mammal a therapeutically effective amount of at least one compound of formula (I), or the pharmaceutically acceptable salt thereof.
Claims20
A compound of formula (I)
- Wherein
- A is a 5 or 6-membered aromatic heterocycle comprising at least one nitrogen atom and optionally 1 sulphur atom and optionally 1 oxygen atom, optionally substituted with at least one group selected from halogen, C1-6 alkyl, C1-6 alkyl substituted with at least one halogen, C1-6 alkoxy, C1-6 alkoxy substituted with at least one halogen, C1-6 alkylthio, and cyano;
- R1 is selected from hydrogen and C1-6 alkyl;
- or A and R1 taken together with the nitrogen atom to which they are linked form a 5-6 membered aromatic or non-aromatic heterocycle containing 1-2 nitrogen atoms, and optionally 1 oxygen atom, and optionally 1 sulphur atom, optionally substituted with a group selected from halogen, C1-6 alkyl, C1-6 alkyl substituted with a halogen, C1-6 alkoxy, C1-6 alkoxy substituted with a halogen, C1-6 alkylthio, ═NH, ═O, —OH, and cyano.
- R2-R3 are independently a group selected from hydrogen and C1-6 alkyl;
- or R2 and R3 taken together with the carbon atom to which they are linked form a C3-4 cycloalkyl;
- R4-R6 are independently a group selected from hydrogen, halogen, and C1-4 alkyl;
- R7-R8 are independently a group selected from hydrogen, C1-4 alkyl, C1-4 alkyl substituted with one OH, C1-4 alkyl substituted with one OC1-3 alkyl, C1-4 alkyl substituted with at least one halogen,
- or R7 and R8 taken together with the carbon atom to which they are linked form a C3-4 cycloalkyl;
- R9-R13 are independently a group selected from hydrogen, halogen, C1-6 alkyl substituted with at least one halogen, C1-6 alkoxy, C1-6 alkoxy substituted with at least one halogen, C1-6 alkylthio, and cyano;
- or
- a pharmaceutically acceptable salt thereof.
9 more elements
Dependencies are inferred from the claim text.