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US 2023/0406825 A1Published application
Compounds, compositions thereof, and methods for treating er+ breast cancer
AssigneeBoard of Regents, The University of Texas System
InventorsMurat Can Cobanoglu, Ganesh Raj
Life of this patent
Estimating the term…
Abstract
Compounds and methods are disclosed for the treatment and/or amelioration of breast cancer. The compounds and methods may treat and/or ameliorate breast cancer by way of activity on isocitrate dehydrogenase 1 (IDH1). The breast cancer may be estrogen receptor positive (ER+) breast cancer. Also disclosed are compositions, including pharmaceutical compositions, for the treatment and/or amelioration of breast cancer.
Claims16
A compound of formula (I), an acid thereof, or a salt thereof:
- wherein
- R1 is a methyl, C2 to C10 unsubstituted aryl, C2 to C10 substituted aryl, C1 to C10 unsubstituted alkyl, C1 to C10 substituted alkyl, C3-C10 unsubstituted cycloalkyl, or C3-C10 substituted cycloalkyl, and
- R2, R3, R4, R5, R6, R7, R8, and R9, are independent selected from hydrogen, methyl, C2 to C10 unsubstituted aryl, C2 to C10 substituted aryl, C1 to C10 unsubstituted alkyl, C1 to C10 substituted alkyl, C3-C10 unsubstituted cycloalkyl, or C3-C10 substituted cycloalkyl.
A composition comprising:
- an amount a compound of formula (I), an acid thereof, or a salt thereof:
- wherein
- R1 is a methyl, C2 to C10 unsubstituted aryl, C2 to C10 substituted aryl, C1 to C10 unsubstituted alkyl, C1 to C10 substituted alkyl, C3-C10 unsubstituted cycloalkyl, or C3-C10 substituted cycloalkyl, and
- R2, R3, R4, R5, R6, R7, R8, and R9, are independent selected from hydrogen, methyl, C2 to C10 unsubstituted aryl, C2 to C10 substituted aryl, C1 to C10 unsubstituted alkyl, C1 to C10 substituted alkyl, C3-C10 unsubstituted cycloalkyl, or C3-C10 substituted cycloalkyl.
1 more element
A method for treating breast cancer in a subject in need thereof comprising:
- administering an effect amount of a compound of formula (I), an acid thereof, or a salt thereof, wherein the compound of formula (I) has the structure:
- wherein
- R1 is a methyl, C2 to C10 unsubstituted aryl, C2 to C10 substituted aryl, C1 to C10 unsubstituted alkyl, C1 to C10 substituted alkyl, C3-C10 unsubstituted cycloalkyl, or C3-C10 substituted cycloalkyl, and
- R2, R3, R4, R5, R6, R7, R8, and R9, are independent selected from hydrogen, methyl, C2 to C10 unsubstituted aryl, C2 to C10 substituted aryl, C1 to C10 unsubstituted alkyl, C1 to C10 substituted alkyl, C3-C10 unsubstituted cycloalkyl, or C3-C10 substituted cycloalkyl.
1 more element
Dependencies are inferred from the claim text.