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US 2023/0406804 A1Published application
Protein kinase inhibitors
AssigneesXavier University of Louisiana, The Administrators of the Tulane Educational Fund
InventorsJayalakshmi SRIDHAR, Frank JONES, Cheryl STEVENS
Life of this patent
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Abstract
The present disclosure relates to compounds that act as protein kinase inhibitors, and the synthesis of the same. Further, the present disclosure teaches the utilization of such compounds in a treatment for proliferative diseases, including cancer, particularly breast cancer, and especially ER+ and/or HER2+ breast cancer.
Claims28
A compound according to Formula (II), and/or a stereoisomer and/or pharmaceutically acceptable salt and/or solvate thereof:
- wherein:
- W, X, Y and Z independently represent hydrogen, —C(R5)—, —O—, —S—, —CH2O—, CH2S—, —(CH2)2O—, —NR6—, —NR6CH2—, —CH2NR6—, —NR6CO—, —CONR6—, —N═N—, —NH—CO—NH—, —NH—CS—NH—, —CO—O—, CO—O—CH2—, —SO2NH—, —NH—SO2—, —CR4═CR4—, —C≡C—, —O—CH2—CO—, —OCH2CH2O—, —CH(OH)—, or —NO2 bridging groups;
- R5 independently represent hydrogen, halogen, C1-6 alkyl, C1-6 alkenyl, C1-6 alkoxy, C1-6haloalkyl, haloC1-6alkoxy, —COOH, —CONH2, —COC1-6 alkyl, O—C1-6 alkyl, NH2, NH—C1-6 alkyl, or —SC1-6 alkyl groups;
- and
- R1, R2, R3, R4 and R6 independently represent hydrogen, halogen, aryl, C3-8 cycloalkyl, monocyclic or bicyclic heterocyclyl, monocyclic or bicyclic heteroaryl, wherein the aryl, heteroaryl or heterocyclyl groups may be optionally substituted by one or more R4 groups.
2 more elements
Dependencies are inferred from the claim text.