Disposable cartridge for reagent storage systems and methods using the same
AssigneeFormulatrix International Holding Ltd.
InventorsKabir YAMANA, Michael NILSSON
Life of this patent
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Abstract
In general, the present application is directed to cartridge assemblies which can be used for reagent storage and systems and methods using the same. Aspects of the present disclosure can include disposable cartridge assemblies that are intended for single-use only. For instance, example cartridge assemblies can include interlocking features that can couple to a to an assay system (e.g., a chip assembly) in an irreversible manner.
Claims28
A system for conducting an assay comprising:
- a cartridge assembly, wherein the cartridge assembly comprises:
- a first surface having a first seal,
- a second surface having a second seal, and
- one or more reservoirs positioned between the first surface and the second surface,
- the reservoirs defining a volume, and wherein at least one of the one or more reservoirs contains a wet reagent;
- and
- a chip assembly, wherein the chip assembly comprises:
- a microfluidic channel, and
- one or more puncture elements configured to pierce the second seal to provide the wet reagent to the chip assembly.
A method for conducting an assay, the method comprising:
- providing a biological sample to a cartridge assembly, wherein the cartridge assembly comprises:
- a first surface having a first seal,
- a second surface having a second seal, and
- one or more reservoirs positioned between the first surface and the second surface, the reservoirs defining a volume, and wherein at least one of the one or more reservoirs contains a wet reagent;
- engaging the cartridge assembly with a chip assembly to transfer the biological sample to the chip assembly, wherein the chip assembly comprises:
- a microfluidic channel, and
- one or more puncture elements configured to pierce the second seal to provide the wet reagent to the chip assembly;
- and
- moving the biological sample through the microfluidic channel, wherein
- after engaging the cartridge assembly with the chip assembly, the one or more reservoirs become fluidically connected to the microfluidic channel.
A cartridge assembly for storing wet reagents, wherein the cartridge assembly comprises:
- a first surface having a first seal,
- a second surface having a second seal, and
- one or more reservoirs positioned between the first surface and the second surface,
- the reservoirs defining a volume, and wherein at least one of the one or more reservoirs contains a polymerase.
Dependencies are inferred from the claim text.