Systems and methods for stimulation parameter contrast (spc) imaging
AssigneeCase Western Reserve University
InventorMichael Moffitt
Life of this patent
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Abstract
An improved neural mapping technique can use two stimulations. The first stimulation can be used to excite a first group of neural elements with a first stimulation parameter set. After the first group of neural elements has entered a refractory state, a second group of neural elements can be excited with a second stimulation parameter set. The response to at least the second stimulation parameter set can be measured and at least one property of constituents of the first group of neural elements and at least one property of constituents of the second group of neural elements can be estimated.
Claims25
A method comprising:
- configuring, by a system comprising a processor, a first stimulation comprising a first parameter set to be delivered to a first location in a stimulation neighborhood to excite a first group of neural elements at the location in the stimulation neighborhood;
- after the first stimulation is applied, collecting, by the system, data related to an excitation of the first group of neural elements;
- configuring, by the system, a second stimulation comprising a second parameter set to be delivered to a second location in the stimulation neighborhood after the first group of neural elements has entered a refractory state from the first stimulation to excite a second group of neural elements at the second location in the stimulation neighborhood;
- after the second stimulation is applied, collecting, by the system, data related to an excitation of the second group of neural elements;
- and
- estimating, by the system, at least one property of constituents of the first group of neural elements and at least one property of constituents of the second group of neural elements based on the data related to the excitation of the first group of neurons and the data related to the excitation of the second group of neurons.
A system comprising:
- at least one implantable electrode configured to apply electrical stimulation;
- a computing device, coupled to the at least one implantable electrode, comprising a memory storing instructions and a processor to execute the instructions to at least:
- configure a first stimulation comprising a first parameter set to be delivered to a location in a stimulation neighborhood to excite a first group of neural elements at the location in the stimulation neighborhood;
- after the first stimulation is applied, collect data related to an excitation of the first group of neural elements;
- configure a second stimulation comprising a second parameter set to be delivered to the location in the stimulation neighborhood after the first group of neural elements has entered a refractory state from the first stimulation to excite a second group of neural elements at the location in the stimulation neighborhood;
- after the second stimulation is applied, collect data related to an excitation of the second group of neural elements;
- and
- estimate properties of constituents of the first group of neural elements and properties of constituents of the second group of neural elements based on the data related to the excitation of the first group of neurons and the data related to the excitation of the second group of neurons.
Dependencies are inferred from the claim text.