Gene therapy for alzheimer's disease
AssigneeCornell University
InventorsRonald G. Crystal et al., Katie M Stiles
Life of this patent
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Abstract
Compositions and methods to prevent, inhibit or treat a disease or disorder associated with expression of APOE4 in a mammal are provided.
Claims33
A gene therapy vector comprising a first promoter operably linked to a nucleic acid sequence comprising an open reading frame encoding APOE2 and a 3′ untranslated region, and an isolated nucleotide sequence comprising one or more RNAi nucleic acid sequences for inhibition of APOE4 mRNA.
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