Back to results
US 2023/0405129 A1Published application
Proinflammatory prodrugs
AssigneeThe Boad of Regents of the University of Taxas System
InventorsHans HAMMERS, Xiankai SUN, Sashi DEBNATH
Life of this patent
Estimating the term…
Abstract
Provided herein are prodrugs comprising targeting moieties that specifically bind extracellular antigens, enzyme-cleavable linkers, and innate immune system activators. An enzyme-cleavable linker can covalently link a targeting moiety to an innate immune system activator. Also provided are methods of treating cancer, methods of imaging cancer, and methods of monitoring treatment of cancer.
Claims28
A prodrug comprising:
- (i) a targeting moiety that specifically binds to an extracellular antigen;
- (ii) a first enzyme-cleavable linker;
- and
- (iii) a first innate immune system activator,
- wherein the first linker covalently links the targeting moiety to the innate immune system activator.
2 more elements
A prodrug selected from:
Dependencies are inferred from the claim text.