Methods of reducing collagenase-mediated bruising in a subject having cellulite
AssigneeEndo Global Aesthetics Limited
InventorsSaji Vijayan, David Hernandez, James Patrick Tursi
Life of this patent
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Abstract
Disclosed herein are methods of reducing collagenase-mediated bruising in a subject having cellulite, methods of treating cellulite in a subject, and collagenase-containing formulations.
Claims52
A method of reducing collagenase-mediated bruising in a subject having cellulite, the method comprising:
- subcutaneously administering to a treatment area of the subject a total dose of about 0.42 mg of collagenase per treatment session to thereby reduce the collagenase-mediated bruising in the subject.
A method of reducing collagenase-mediated bruising in a subject having cellulite, the method comprising:
- subcutaneously administering to a treatment area of the subject a total dose of about 0.84 mg of collagenase per treatment session, the collagenase having a concentration of about 0.05 mg/ml, to thereby reduce the collagenase-mediated bruising in the subject.
A method of reducing collagenase-mediated bruising in a subject having cellulite, the method comprising:
- subcutaneously administering to a treatment area of the subject a total dose of about 0.84 mg of collagenase per treatment session at a depth of about 0.25 inches to thereby reduce the collagenase-mediated bruising in the subject.
A method of reducing collagenase-mediated bruising in a subject having cellulite, the method comprising:
- subcutaneously administering to a treatment area of the subject a total dose of about 0.84 mg of collagenase per treatment session, the collagenase having a concentration of about 0.09 mg/ml, to thereby reduce the collagenase-mediated bruising in the subject.
A method of reducing collagenase-mediated bruising in a subject having cellulite, the method comprising:
- subcutaneously administering to a treatment area of the subject a composition comprising collagenase, lidocaine, and epinephrine, wherein a total dose of about 0.42 mg of the collagenase is administered per treatment session to thereby reduce the collagenase-mediated bruising in the subject.
A method of reducing collagenase-mediated bruising in a subject having cellulite, the method comprising:
- subcutaneously administering to a treatment area of the subject a total dose of about 0.21 mg of collagenase per treatment session, the collagenase having a concentration of about 0.12 mg/ml, to thereby reduce the collagenase-mediated bruising in the subject.
A method of treating cellulite in a subject, the method comprising:
- a) subcutaneously administering to a treatment area of the subject a total dose of about 0.42 mg of collagenase per treatment session to thereby treat the cellulite in the subject;
- b) subcutaneously administering to a treatment area of the subject a total dose of about 0.84 mg of collagenase per treatment session, the collagenase having a concentration of about 0.05 mg/ml, to thereby treat the cellulite in the subject;
- c) subcutaneously administering to a treatment area of the subject a total dose of about 0.84 mg of collagenase per treatment session, the collagenase having a concentration of about 0.23 mg/ml, at a depth of about 0.25 inches to thereby treat the cellulite in the subject;
- d) subcutaneously administering to a treatment area of the subject a total dose of about 0.84 mg of collagenase per treatment session, the collagenase having a concentration of about 0.09 mg/ml, to thereby treat the cellulite in the subject;
- e) subcutaneously administering to a treatment area of the subject a composition comprising collagenase, lidocaine, and epinephrine, wherein a total dose of about 0.42 mg of the collagenase is administered per treatment session to thereby treat the cellulite in the subject;
- or
- f) subcutaneously administering to a treatment area of the subject a total dose of about 0.21 mg of collagenase per treatment session, the collagenase having a concentration of about 0.12 mg/ml, to thereby treat the cellulite in the subject.
A formulation comprising:
- a collagenase;
- lidocaine;
- and
- epinephrine.
Dependencies are inferred from the claim text.