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OwnerGerrit Klaerner, Eric F. Connor +8inventors
InventorsGerrit Klaerner, Eric F. Connor, Randi K. Gbur, Matthew J. Kade, Paul H. Kierstead, Jerry M. Buysse, Michael J. Cope, Kalpesh N. Biyani, Son H. Nguyen, Scott M. Tabakman
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Pharmaceutical compositions for and methods of treating an animal, including a human, and methods of preparing such compositions. The pharmaceutical compositions contain crosslinked amine polymers and may be used, for example, to treat diseases or other metabolic conditions in which removal of protons and/or chloride ions from the gastrointestinal tract would provide physiological benefits such as normalizing serum bicarbonate concentrations and the blood pH in an animal, including a human.
1-115. (canceled)
A pharmaceutical composition comprising a crosslinked amine polymer, the crosslinked amine polymer comprising residues of a monoallylamine, a multifunctional allylamine, and dichloroethane.
A pharmaceutical composition comprising a crosslinked amine polymer, the crosslinked amine polymer comprising the residues of (i) allylamine or a salt thereof, (ii) DAPDA or a salt thereof, and (iii) dichloroethane.
A pharmaceutical composition comprising a crosslinked amine polymer, which is made by a two-step reaction comprising (i) preparing a preformed amine polymer comprising residues of diallylpropyldiamine (DAPDA) or a salt thereof and residues of allylamine (AAH) or a salt thereof and (ii) crosslinking the preformed polymer with dichloroethane (DCE) to form a cross-linked amine polymer, the cross-linked amine polymer comprising at least one dichloroethane residue.
Dependencies are inferred from the claim text.