miR-29a-LIKE NUCLEIC ACID REAGENT, LIVER FIBROSIS INHIBITOR, AND PHARMACEUTICAL COMPOSITION
AssigneeTokyo Medical University
InventorsYoshiki MURAKAMI, Masahiko KURODA
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Abstract
Provided are an miR-29a-like nucleic acid reagent and a pharmaceutical composition that aim to inhibit liver fibrosis. An miR-29a-like nucleic acid reagent according to the present invention includes nucleic acid having a base sequence of Sequence ID No. 1 that includes DNA and RNA and in which at least one nucleotide residue is a modified residue: Sequence ID No. 1: uagcaccaggctgucc. A liver fibrosis inhibitor and a pharmaceutical composition according to the present invention include the miR-29a-like nucleic acid reagent according to the present invention, and are preferably used for oral administration.
Claims22
An miR-29a-like nucleic acid reagent comprising nucleic acid having a base sequence of SEQ ID NO:
- 1 that includes DNA and RNA and in which at least one nucleotide residue is a modified residue:
- uagcaccaggctgucc (SEQ ID NO:
- 1).
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Dependencies are inferred from the claim text.