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AssigneeIcahn School of Medicine at Mount Sinai
InventorsErnesto GUCCIONE, Amaia LUJAMBIO, Arvin DAR, Alexander RIALDI, Mary E. DUFFY, Alexander P. SCOPTON, Pedro MOLINA-SANCHEZ, Slim MZOUGHI
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The present disclosure relates to methods of treating tumors and cancers having dysregulated Wnt signaling pathways with compounds of Formula (I) having the following structure: (I) or a stereoisomer, pharmaceutically acceptable salt, oxide, or solvate thereof, where X is a halogen and R is a phenyl substituted with a perfluoroalkane. Also disclosed is a method of treating a tumor, which involves contacting a tumor comprising cytoplasmic EZH2 with a kinase inhibitor compound under conditions effective to treat the tumor.
A method of treating a tumor having a dysregulated Wnt signaling pathway, said method comprising:
The method according to any one of the preceding claims, wherein the tumor is associated with a colorectal cancer;
The method according to any one of the preceding claims further comprising:
The method according to any one of the preceding claims, wherein in the compound of Formula (I) X is fluorine.
The method according to any one of the preceding claims, wherein in the compound of Formula (I) R is a phenyl substituted with C2F5 or C3F7.
The method according to any one of the preceding claims, wherein the compound of Formula (I) has a chemical structure of
The method according to any one of the preceding claims, wherein said contacting with a compound of Formula (I) is carried out in vitro.
A method of treating a cancer having a dysregulated Wnt signaling pathway in a subject in need thereof, said method comprising:
A method of treating a tumor, said method comprising:
Dependencies are inferred from the claim text.