Methods to sensitize cancer cells to immune attack using atractylenolide i
AssigneeThe Trustees of Indiana University
InventorsXiongbin LU, Xinna ZHANG, Kevin VAN DER JEUGHT
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Abstract
The present disclosure relates to compositions and methods to induce or increase immunogenicity in cancerous cells comprising contacting the cancerous cells with atractylenolide I (ATT-I). In some embodiments, the methods include contacting the cancerous cells with ATT-I in combination with a cancer therapeutic agent.
Claims16
A method of enhancing the efficacy of CD8+ T cell cytotoxicity against a cancerous cell, the method comprising contacting said cancerous cell with atractylenolide (ATT-I).
A method of increasing the presentation of antigen-loaded MHC-I complex on a cancer cell, said method comprising contacting said cancer cell with ATT-I.
A method of treating cancer, said method comprising administering to a patient having cancer a pharmaceutical composition comprising atractylenolide (ATT-I).
Dependencies are inferred from the claim text.