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US 2023/0404930 A1Published application
Metal organic framework/porous silicate and/or aluminosilicate nanocarrier for blastocystosis treatment
AssigneeImam Abdulrahman Bin Faisal University
InventorsB. Rabindran JERMY, Vijaya RAVINAYAGAM, Ayman A. ELBADRY
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Abstract
A nanomedicinal composition comprising a nanocarrier and an antioxidant. The nanocarrier contains a metal organic framework and a porous silicate and/or aluminosilicate matrix. The antioxidant is disposed in the pores and/or on the surface of the nanocarrier by a solution phase impregnation process. The nanomedicinal composition is used in a method of treating Blastocystis infection.
Claims17
A nanomedicinal composition, comprising:
- a nanocarrier comprising:
- a metal organic framework which is a zeolitic imidazolate framework, and
- a porous silicate and/or aluminosilicate matrix, wherein the porous silicate and/or aluminosilicate matrix is present in an amount of 1 to 20 wt % based on a total weight of the nanocarrier;
- and
- an antioxidant disposed in the pores and/or on a surface of the nanocarrier,
- wherein the antioxidant is Resveratrol in phenolic form or Curcumin in phenolic form;
- wherein the nanocarrier has a surface area of 225 to 750 m2/g, a pore volume of 0.25 to 0.85 cm3/g, and a mean pore size of 2 to 10 nm,
- wherein said nanomedicinal composition reduces the viability of Blastocystis organisms by at least 75% when they are exposed to 100 to 1000 μg/mL of the nanomedicinal composition for 24 hours in vitro.
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Dependencies are inferred from the claim text.