A device for treatment of the left atrial appendage

A device (10) to occlude the left atrial appendage (1) of a heart of a subject, comprising:

• an implantable occlusion apparatus (30) configured for radial expansion upon deployment to fluidically occlude the left atrial appendage;
• an elongated catheter member (80) having a distal end attachable to the implantable occlusion apparatus for transluminal delivery of the implantable occlusion apparatus to the left atrial appendage;
• a tissue energising module (20) having a plurality of electrodes (26) disposed around a circumference of the implantable occlusion apparatus in which each electrode is configured to contact a wall of the left atrial appendage at a tissue focal point upon deployment of the implantable occlusion apparatus;
• and
• an electrical controller (40) including a pulsed field energy delivery generator operably attachable to an electrical power source (50) and the plurality of electrodes (26) and configured to energise the electrodes in a pulsed field ablation modality, in which the electrical controller (40) is configured to energise the plurality of electrodes (26) independently to apply a non-uniform pulsed field ablation treatment circumferentially around the wall of the left atrial appendage
• characterised in that the device comprises a processor (60) operably coupled to the electrical controller (40) and configured to generate an electrical parameter profile of the LAA comprising electrical parameter measurements taken at a plurality of sections around the circumference of the wall of the LAA and modify the output of the electrical controller so as to independently energise the electrodes (26) or sets of electrodes in a pattern synergistic with the tissue parameter profile to energise some electrodes or sets of electrodes with greater ablative power than others to create a non-uniform tissue ablation circumferentially around the wall of the LAA, tuned to the specific anatomy of the subject.