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US 2023/0404064 A1Published application
Modified donor organs
OwnerShaf KESHAVJEE, Marcelo CYPELinventors
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Abstract
A repaired ex vivo organ suitable for transplantation in a human, said repaired ex vivo organ having undergone ex vivo organ perfusion for a maintenance period, wherein said organ had been assessed as being unsuitable for transplantation into a human before the maintenance period and was determined to be suitable for transplantation after the maintenance period.
Claims21
A repaired ex vivo lung for transplantation into a human recipient, comprising:
- (i) a substantially bloodless perfusate at body temperature comprising:
- (a) methylprednisolone,
- (b) cilastatin and imipenem, and/or
- (c) heparin,
- and
- (ii) exogenous stem cells that ameliorate injury or inflammation in the ex vivo lung, wherein the lung is from a human donor and wherein the exogenous stem cells are from a source other than the human donor and a source other than the human recipient.
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