Optimal multi-electrode transcutaneous stimulation with high focality and intensity
AssigneeThe Regents of the University of California
InventorsYing Li, Wentai Liu, Yi-Kai Lo
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Abstract
Methods, apparatus, and systems are disclosed for optimization techniques and a realistic 3D model to design optimal parameters for transcutaneous stimulation to achieve focalized stimulation of a target tissue such as the spinal cord, brain or other internal organ. The methods, apparatus, and systems include generation of a 3D model from a CT/MRI image, as well as an optimization algorithm that enables stimulation of any target location (e.g., on the dorsal root, or on the dorsal column) with any orientation at high precision.
Claims16
A system for transcutaneous stimulation therapy using optimized parameters, the system comprising:
- an array comprising multiple stimulation electrodes in a stimulator electrode array;
- a stimulator circuit configured to provide independent stimulation signals to individual electrodes in said stimulator electrode array at a plurality of frequencies, intensities, and/or waveforms;
- a processor configured to control said stimulator circuit;
- and
- a non-transitory memory storing instructions executable by the processor;
- wherein said instructions, when executed by the processor, perform steps comprising:
- generating a 3D model of the target treatment region and stimulator electrode array as applied proximal the target treatment region;
- calculating a lead field matrix associated with the stimulation electrode array and the target treatment region;
- determining a safety limit for transcutaneous stimulation of the target treatment region;
- generating a set of optimal stimulation parameters based on the lead field matrix and the safety limit, where the stimulation parameters provide both high intensity and focal accuracy within the safety limit using a parameter which assigns a relative weight to directional intensity and focality of stimulation at the target treatment region;
- and
- configuring said stimulator circuit to operate utilizing the generated optimal stimulation parameters.
Dependencies are inferred from the claim text.