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US 2023/0400466 A1Published application
Methods and systems for risk stratification and management of bladder cancer
AssigneeUniversity of Houston System
InventorsChandra Mohan, Kamala Vanarsa
Life of this patent
Estimating the term…
Abstract
Non-invasive methods of risk stratification and treatment of bladder cancer in a subject are based on evaluating D-dimer in a urine sample of the subject, and assay systems thereof for evaluation of D-dimer in the urine sample.
Claims20
A method for identifying a subject for an invasive testing for bladder cancer, the method comprising:
- obtaining a first urine sample from the subject;
- assessing an elevated level of D-dimer in a urine sample obtained from the subject as compared to a predetermined threshold level;
- determining that the subject is at increased risk of having bladder cancer based on the elevated level of D-dimer in the urine sample;
- and
- performing an invasive testing for the bladder cancer on the subject.
2 more elements
A method for treating a subject for bladder cancer, the method comprising:
- (a) assessing an increased level of D-dimer in a urine sample obtained from the subject as compared to a predetermined threshold level through an enzyme-linked immunosorbent assay (ELISA) or a lateral flow assay (LFA);
- (b) in response to the level of D-dimer in the urine sample being above the predetermined threshold, identifying the subject as at increased risk of having bladder cancer;
- (c) performing an invasive testing for the bladder cancer on the subject;
- (d) determining that the subject has the bladder cancer based on results of the invasive testing;
- and
- (e) treating the subject for the bladder cancer by one or more of surgical resection, radiation, chemotherapy, and hormone therapy.
3 more elements
An assay system for assessing a level of D-dimer in a urine sample, for use in risk stratification for bladder cancer.
Dependencies are inferred from the claim text.