Nucleic acid delivery scaffolds

A method of forming a multilayer polymer composition, said method comprising:

• contacting a solid support with a first plurality of first particles to form a first layer of first particles, wherein each first particle comprises a first degradable particle core and a first polymer shell attached to said particle core, wherein said first polymer shell comprises a first bioconjugate reactive moiety;
• contacting the first layer of first particles with a first degrading agent and decomposing the first degradable particle core and forming a first polymer layer;
• contacting the solid support with a second plurality of second particles to form a second layer of second particles, wherein each second particle comprises a second degradable particle core and a second polymer shell attached to said particle core, wherein said second polymer shell comprises a second bioconjugate reactive moiety;
• and
• contacting the second with a second degrading agent and decomposing the second degradable particle core and forming a second polymer layer, thereby forming a multilayer polymer composition.