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US 2023/0399685 A1Published application
Methods and systems for detecting tissue conditions
AssigneeMolecular Stethoscope, Inc.
InventorsMichael NERENBERG, Neeraj SALATHIA, Arkaitz IBARRA, Yue ZHAO
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Abstract
Provided herein are methods and systems for detecting tissue conditions. In some aspects, levels of one or more markers of a disease or condition and one or more tissue-specific cell-free polynucleotides are quantified, levels are compared to a reference, and it is determined whether the tissue has been damaged by the disease or condition based on the comparing. Systems for performing the methods described herein are also provided.
Claims20
A method comprising:
- a) obtaining a blood sample from a subject;
- b) removing cells from the blood sample to obtain a cell-depleted sample;
- c) removing an extracellular microparticle from the cell-depleted sample to obtain a microparticle-depleted sample;
- and
- d) quantifying an amount of cell-free ribonucleic acid (RNA) corresponding to a gene in the microparticle-depleted sample.
2 more elements
Dependencies are inferred from the claim text.