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US 2023/0399640 A1Published application
Compositions and methods for inhibiting gene expression
AssigneeFlagship Pioneering Innovations V, Inc.
InventorsJodi Michelle KENNEDY, Jeremiah Dale FARELLI
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Abstract
The present disclosure relates to expression repressors and expression repression systems for modulating expression of a target gene in a cell.
Claims42
An expression repression system comprising:
- a first expression repressor comprising a first DNA-targeting moiety and a first repressor domain, and
- a second expression repressor comprising a second DNA-targeting moiety and a second repressor domain,
- wherein the first DNA-targeting moiety specifically binds a first DNA sequence, and the second DNA-targeting moiety specifically binds a second DNA sequence different from the first DNA sequence, and
- wherein the first repressor domain is different from the second repressor domain.
1 more element
An expression repression system comprising:
- a first expression repressor comprising a first DNA-targeting moiety and a first repressor domain, and
- a second expression repressor comprising a second DNA-targeting moiety and a second repressor domain,
- wherein the first or second repressor domain comprises an MQ1 domain or functional variant or fragment thereof,
- wherein the first repressor domain is different from the second repressor domain.
1 more element
A polypeptide comprising:
- a DNA-targeting moiety;
- and
- a repressor domain comprising bacterial MQ1 or a functional variant or fragment thereof.
Dependencies are inferred from the claim text.