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US 2023/0399622 A1Published application
Therapy for degenerative disease and tissue damage
OwnerMaria Pia COSMA, Martina PESARESIinventors
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OwnerMaria Pia COSMA, Martina PESARESIinventors
Estimating the term…
A genetically-modified stem cell comprises an exogenous nucleic acid encoding a chemokine receptor. The exogenous nucleic acid is operably linked to at least one promoter and/or enhancer sequence for expression of the chemokine receptor in the genetically-modified stem cell. The chemokine receptor may be selected from Ccr5, Cxcr6, Ccr1, Cxcr2 and/or Ccr3. The genetical-ly-modified stem cell may be used in a method for the treatment of tissue damage and/or degenerative disease, such as an eye disease or disorder. A modified viral vector packaging a recombinant viral-based genome, for use in a method of treating a subject suffering from tissue damage and/or degenerative disease, such as an eye disease or disorder is also described. Methods for treating tissue damage and/or degenerative disease, such as eye diseases or disorders, and pharmaceutical compositions for use in such methods are also described.
A genetically-modified stem cell comprising an exogenous nucleic acid encoding a chemokine receptor, wherein the exogenous nucleic acid is operably linked to at least one promoter and/or enhancer sequence for expression of the chemokine receptor in the genetically-modified stem cell.
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A method for treating a subject suffering from an eye disease or disorder, the method comprising:
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A method of producing a genetically-modified stem cell, comprising contacting a stem cell with one or more modified viral vectors packaging a recombinant viral-based genome, wherein the recombinant viral-based genome comprises a cDNA insert encoding an exogenous chemokine receptor polypeptide, such that the one or more modified viral vectors infects and causes increased expression of the chemokine receptor in the stem cell.
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Dependencies are inferred from the claim text.