Phthalocyanine dye compounds, conjugates and methods of use thereof
AssigneeRakuten Medical, Inc.
InventorsJuan BETANCORT, Lew MAKINGS, Torsten WIEMANN, Robert J. HOEY
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Abstract
Disclosed herein are phthalocyanine dyes, and conjugates thereof, useful as fluorescent reporters for bioassays, for optical imaging and as therapeutic conjugates as the photosensitizing agents in light-based therapies including photoimmuno therapy (PIT). Certain phthalocyanine dyes disclosed herein are water soluble, and possess photophysical and photochemical profiles useful for use in imaging or therapy.
Claims21
-145. (canceled)
A compound, or salt, stereoisomer, or tautomer thereof, comprising a silicon atom coordinated by (a) an unsubstituted phthalocyanine, (b) a first axial silicon-containing ligand comprising a conjugatable group;
- and (c) a second axial silicon-containing ligand comprising a water-solubilizing group, but not a conjugatable group;
- and wherein the chemical structures of the first and second axial ligands are different.
Dependencies are inferred from the claim text.