Composition comprising a highly substituted hydroxypropyl methylcellulose and a sugar alcohol
AssigneeNutrition & Bioscinces USA 1, LLC
InventorsKevin O'Donnell, Rebecca Putans, Oliver Petermann, Roland Bayer, Rene Kelling, Wesley Spaulding
Life of this patent
Estimating the term…
Abstract
A composition comprises a mixture of a hydroxypropyl methylcellulose having a DS of from 1.0 to 2.7 and an MS of from 0.40 to 1.30, wherein the sum of the DS and MS is from 1.8 to 3.6, and wherein DS is the degree of substitution of methoxyl groups and MS is the molar substitution of hydroxypropoxyl groups, and a sugar alcohol in a weight ratio of hydroxypropyl methylcellulose to sugar alcohol of from 98:2 to 85:15. The composition may for instance be used to purge extrusion equipment.
Claims23
A composition comprising a mixture of a hydroxypropyl methylcellulose having a DS of from 1.0 to 2.7 and an MS of from 0.40 to 1.30, wherein the sum of the DS and MS is from 1.8 to 3.6, and wherein DS is the degree of substitution of methoxyl groups and MS is the molar substitution of hydroxypropoxyl groups, and a sugar alcohol in a weight ratio of hydroxypropyl methylcellulose to sugar alcohol of from 98:2 to 85:15.
A process for reducing the tackiness of a highly substituted hydroxypropyl methylcellulose during hot melt extrusion, the process comprising the steps of
- a) blending a hydroxypropyl methylcellulose having a DS of from 1.0 to 2.7 and an MS of from 0.40 to 1.30, wherein the sum of the DS and MS is from 1.8 to 3.6, and wherein DS is the degree of substitution of methoxyl groups and MS is the molar substitution of hydroxypropoxyl groups, and a sugar alcohol in a weight ratio of hydroxypropyl methylcellulose to sugar alcohol of from 98:2 to 85:15,
- b) subjecting the blend of step b) to extrusion at a temperature of from 95° C. to 230° C., and
- c) recovering the extruded mass from the extruder.
15-16. (canceled)
A process for purging extrusion equipment of a contaminant material adhered to interior surfaces of said equipment, the process comprising
- a) charging the extrusion equipment with a purging composition comprising a mixture of a hydroxypropyl methylcellulose having a DS of from 1.0 to 2.7 and an MS of from 0.40 to 1.30, wherein the sum of the DS and MS is from 1.8 to 3.6, and wherein DS is the degree of substitution of methoxyl groups and MS is the molar substitution of hydroxypropoxyl groups, and a sugar alcohol in a weight ratio of hydroxypropyl methylcellulose and sugar alcohol of from 98:2 to 85:15,
- b) conveying the purging composition through the extrusion equipment, and
- c) removing the purging composition from the extrusion equipment, whereby substantially all the contaminant material adhered to an interior surface of the extrusion equipment is removed.
21-23. (canceled)
(canceled)
Dependencies are inferred from the claim text.