Bioactive Synthetic Copolymer, Bioactive Macromolecule and Related Methods Thereof

A bioactive synthetic copolymer with a poly(norbornene) backbone comprising one or more repeating units represented by general formula (I) and one or more repeating units represented by general formula (II):

• wherein
• R1 is optionally substituted alkyl;
• R2 is selected from a single bond, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted alkoxyalkyl, optionally substituted alkylcarbonyl or optionally substituted alkylcarbonylalkyl;
• R3 is selected from H, optionally substituted alkyl, optionally substituted alkenyl or optionally substituted alkynyl;
• L is heteroalkylene;
• X comprises a bioactive moiety selected from the group consisting of proteins, peptides, carbohydrates, therapeutic/drug molecules and derivatives thereof;
• Y1 comprises a synthetic polymer or parts thereof;
• and
• Z1 and Z2 are each independently selected from CRaRb, O, NRc, SiRaRb, PRa or S, wherein Ra, Rb and Rc are each independently selected from the group consisting of H, optionally substituted alkyl, optionally substituted alkenyl and optionally substituted alkynyl.