Antibodies for opioid treatments
AssigneeThe Scripps Research Institute
InventorsKim D. Janda, Paul T. Bremer, Bin Zhou
Life of this patent
Estimating the term…
Abstract
The disclosure provides, inter alia, antibodies, pharmaceutical compositions containing antibodies, and the use of the antibodies and pharmaceutical compositions to treat or prevent opioid overdoses, to treat opioid use disorder, and to treat or prevent opioid-induced respiratory depression.
Claims31
An antibody comprising:
- (i) a light chain variable region which comprises a CDR L1 having an amino acid sequence with at least 95% sequence identity to SEQ ID NO:1, a CDR L2 having an amino acid sequence with at least 95% sequence identity to SEQ ID NO:2, and a CDR L3 having an amino acid sequence with at least 95% sequence identity to SEQ ID NO:3;
- and
- (ii) a heavy chain variable region which comprises:
- a CDR H1 having an amino acid sequence with at least 95% sequence identity to SEQ ID NO:15, a CDR H2 having an amino acid sequence with at least 95% sequence identity to SEQ ID NO:16, and a CDR H3 having an amino acid sequence with at least 95% sequence identity to SEQ ID NO:6.
An antibody comprising:
- (i) a light chain variable region which comprises a CDR L1 having an amino acid sequence with at least 95% sequence identity to SEQ ID NO:1, a CDR L2 having an amino acid sequence with at least 95% sequence identity to SEQ ID NO:2, and a CDR L3 having an amino acid sequence with at least 95% sequence identity to SEQ ID NO:3;
- and
- (ii) a heavy chain variable region which comprises a CDR H1 having an amino acid sequence with at least 95% sequence identity to SEQ ID NO:4, a CDR H2 having an amino acid sequence with at least 95% sequence identity to SEQ ID NO:5, and a CDR H3 having an amino acid sequence with at least 95% sequence identity to SEQ ID NO:6.
An antibody comprising a light chain variable region having at least 85% sequence identity to SEQ ID NO:20 and a heavy chain variable region having at least 85% sequence identity to SEQ ID NO:23.
An isolated nucleic acid having a nucleic acid sequence with at least 85% sequence identity to SEQ ID NO:26, SEQ ID NO:27, or SEQ ID NO:28.
Dependencies are inferred from the claim text.