Optimized antibody variable regions
AssigneeXencor, Inc.
InventorsGregory Moore, Matthew Bernett, Rumana Rashid, John Desjarlais
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Abstract
The present invention is directed to optimized anti-CD3 variable sequences for use in a variety of bispecific formats, including those that utilize scFv components. The invention further relates to nucleic acids encoding for the polypeptide, to vectors comprising the same and to host cells comprising the vector. In another aspect, the invention provides for a pharmaceutical composition comprising the mentioned polypeptide and medical uses of the polypeptide.
Claims2
-83. (canceled)
A construct comprising an anti-CD3 binding domain, said anti-CD3 binding domain comprising a variable heavy chain having at least 95% identity to the amino acid sequence of SEQ ID NO:
- 397 and a variable light chain having at least 95% identity to the amino acid sequence of SEQ ID NO:
- 398.
Dependencies are inferred from the claim text.