Novel anti-nogo-a antibodies
AssigneeNovaGo Therapeutics AG
InventorsBenoit COMBALUZIER, Eduardo Paulo Morawski VIANNA, Michael Andreas MAURER
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Abstract
Provided are novel human-derived monoclonal neutralizing Nogo-A specific antibodies as well as fragments, derivatives and variants thereof as well as methods related thereto. Polynucleotides, vectors, host cells and kits related to the Nogo-A specific antibodies are also provided. The antibodies, immunoglobulin chain(s), as well as binding fragments, derivatives and variants thereof can be used in pharmaceutical and diagnostic compositions for Nogo-A targeted immunotherapy and diagnosis, respectively.
Claims25
A human-derived recombinant monoclonal anti-Nogo-A antibody or antigen-binding fragment thereof, wherein the antibody or antigen-binding fragment thereof binds to the Nogo-A-Δ20 domain and is capable of inducing dose dependent neurite outgrowth and/or angiogenesis in stroke penumbra.
Dependencies are inferred from the claim text.