Antibodies for use in the detection and treatment of heart disease
AssigneesMUSC Foundation for Research Development, Board of Regents, The University of Texas System
InventorsFederica DEL MONTE, Rakez KAYED
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Abstract
The present disclosure is directed to method of diagnosing and treating heart disease using antibodies that bind to Cofilin, Aβ and/or Tau.
Claims27
A method of detecting a misfolded protein in the heart tissue of a subject comprising:
- (a) contacting a heart tissue sample from said subject with an antibody or antibody fragment that binds to Cofilin, Aβ or Tau;
- and
- (b) detecting Cofilin, Aβ or Tau in said sample by binding of said antibody or antibody fragment to a Cofilin, Aβ or Tau in said sample.
6-8. (canceled)
A method of treating a subject with heart disease characterized by misfolded proteins in cardiac tissue, or reducing the likelihood of the same, comprising delivering to said subject an antibody or antibody fragment that binds to Cofilin, Aβ or Tau.
11-13. (canceled)
(canceled)
A vaccine formulation comprising one or more antibodies or antibody fragments that bind to Cofilin, Aβ and/or Tau.
21-24. (canceled)
A vaccine formulation comprising one or more expression vectors encoding a first antibody or antibody fragment that binds to Cofilin, Aβ or Tau.
Dependencies are inferred from the claim text.