Antibodies to coronavirus spike protein and methods of use thereof

An isolate isolated monoclonal antibody or an antigen-binding fragment thereof comprising a heavy chain variable region (VH) and a light chain variable region (VL) comprising six immunoglobulin complementarity determining regions HCDR1, HCDR2, HCDR3, LCDR1, LCDR2, and LCDR3, wherein the HCDR1, HCDR2, HCDR3, LCDR1, LCDR2, and LCDR3, comprise, respectively, the amino acid sequences SEQ ID NO:

• 31, SEQ ID NO:
• 32, SEQ ID NO:
• 33, SEQ ID NO:
• 34, SEQ ID NO:
• 35, and SEQ ID NO:
• 36;
• SEQ ID NO:
• 43, SEQ ID NO:
• 44, SEQ ID NO:
• 45, SEQ ID NO:
• 46, SEQ ID NO:
• 47, and SEQ ID NO:
• 48;
• SEQ ID NO:
• 55, SEQ ID NO:
• 56, SEQ ID NO:
• 57, SEQ ID NO:
• 58, SEQ ID NO:
• 59, and SEQ ID NO:
• 60;
• SEQ ID NO:
• 67, SEQ ID NO:
• 68, SEQ ID NO:
• 69, SEQ ID NO:
• 70, SEQ ID NO:
• 71, and SEQ ID NO:
• 72;
• SEQ ID NO:
• 79, SEQ ID NO:
• 80, SEQ ID NO:
• 81, SEQ ID NO:
• 82, SEQ ID NO:
• 83, and SEQ ID NO:
• 84;
• SEQ ID NO:
• 133, SEQ ID NO:
• 134, SEQ ID NO:
• 135, SEQ ID NO:
• 136, SEQ ID NO:
• 137, and SEQ ID NO:
• 138;
• SEQ ID NO:
• 187, SEQ ID NO:
• 188, SEQ ID NO:
• 189, SEQ ID NO:
• 190, SEQ ID NO:
• 191, and SEQ ID NO:
• 192;
• SEQ ID NO:
• 193, SEQ ID NO:
• 194, SEQ ID NO:
• 195, SEQ ID NO:
• 196, SEQ ID NO:
• 197, and SEQ ID NO:
• 198;
• SEQ ID NO:
• 199, SEQ ID NO:
• 200, SEQ ID NO:
• 201, SEQ ID NO:
• 202, SEQ ID NO:
• 203, and SEQ ID NO:
• 204;
• SEQ ID NO:
• 205, SEQ ID NO:
• 206, SEQ ID NO:
• 207, SEQ ID NO:
• 208, SEQ ID NO:
• 209, and SEQ ID NO:
• 210;
• SEQ ID NO:
• 211, SEQ ID NO:
• 212, SEQ ID NO:
• 213, SEQ ID NO:
• 214, SEQ ID NO:
• 215, and SEQ ID NO:
• 216;
• or SEQ ID NO:
• 217, SEQ ID NO:
• 218, SEQ ID NO:
• 219, SEQ ID NO:
• 220, SEQ ID NO:
• 221, and SEQ ID NO:
• 222.