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US 2023/0399374 A1Published application
Compounds, Compositions and Methods of Use to Treat Bone Fractures
AssigneePurdue Research Foundation
InventorsPhilip Stewart LOW, Stewart A. LOW, Jeffrey Jay Howard NIELSEN
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Abstract
Osteotropic ligand-bone anabolic agent compounds and related compositions and methods of use to treat bone fractures.
Claims50
A compound having a structure of Formula (I)
- X—Y—Z Formula (I),
- or a pharmaceutically acceptable salt thereof,
- wherein:
- X is a bone anabolic agent selected from the group consisting of a parathyroid hormone (PTH) or a derivative or fragment thereof, a PTH-related protein (PTHrP) or a derivative or fragment thereof, and abaloparatide or a derivative or fragment thereof;
- Y is absent, a releasable linker or a non-releasable linker;
- and
- Z is an osteotropic ligand.
4 more elements
The compound of any one of the preceding claims, wherein the bone anabolic agent is abaloparatide or a derivative or fragment thereof having bone anabolic activity.
A pharmaceutical composition comprising a compound of any one of the preceding claims, or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.