Tetrapeptides, compositions comprising them, and their cosmetic use

Abstract

They have the general Formula X-(Xaa)nPG(Xaa)m-Z wherein Xaa is either A or V, either n=2 and m=0, or n=1 and m=1, at the N-terminal end X being selected from H, —CO—R1, —SO2—R1 or a biotinyl group, at the C-terminal end Z being selected from OH, OR1, NH2, NHR1 or NR1R2, and R1 and R2 being selected from an alkyle, aryle, aralkyle, alkylaryl, alkoxy, saccharide and aryloxy, said group having from 1 to 24 carbon atoms. Preferred peptide sequences are X-AVPG-Z and X-VPGA-Z. These tetrapeptides stimulate the synthesis of molecules constituting the dermal extracellular matrix, in particular collagen 1 and 4 and fibronectin, and can be used for a cosmetic treatment, in particular anti-aging, anti-wrinkle and fine lines, to improve the skin mechanical properties, firmness/tone/elasticity/flexibility, to increase skin density and volume, for a restructuring effect and/or to fight against stretch marks, and skin sagging.

Dependencies are inferred from the claim text.