Amino acid derivative of glucosamine stimulating extracellular matrix synthesis and pharmaceutical composition comprising the same
AssigneeCartilago S.R.L.
InventorsFilippo SURACE, Roberto SCANDURRA
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Abstract
The present patent application relates to the use of an innovative amino acid derivative of glucosamine having the Formula 1 of the general structure which follows, or of a pharmaceutical composition which contains it as a single active ingredient or in association with one or more further active ingredients for the preparation of a medicament for the treatment or prophylaxis of diseases involved mainly with the regulation of the turnover of macromolecules that make up the ECM of connective tissue in general and more specifically of the cartilage.
Claims20
1-10. (canceled)
An injectable solution pharmaceutical composition comprising an amino acid derivative of glucosamine having the following Formula 1 of general structure:
- or the pharmaceutically acceptable salt, solvate, hydrate or stereoisomer thereof, wherein the group R represents an amino acid, an N-acyl derivative of an amino acid or an N-acyl derivative of a peptide and wherein the amine group of glucosamine is bound by amide bond to the carboxyl side chain of said amino acid;
- wherein the pharmaceutical composition comprises the amino acid derivative of glucosamine at a concentration of between 0.5% by weight and 4.5% by weight, together with carriers suitable for injection.
Dependencies are inferred from the claim text.