US 2023/0399343 A1 · PROCESS OF MAKING CFTR MODULATORS

Process of making cftr modulators

AssigneeVertex Pharmaceuticals Incorporated

InventorsPaul Angell, John E. Cochran, Benjamin J. Littler, David Siesel, Armando Urbina, Corey Don Anderson, Jeremy J. Clemens, Thomas Cleveland, Timothy Richard Coon, Bryan Frieman, Peter Grootenhuis, Sara Sabina Hadida Ruah, Jason McCartney, Mark Thomas Miller, Prasuna Paraselli, Fabrice Pierre, Sara E. Swift, Jinglan Zhou

Life of this patent

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Abstract

The disclosure provides processes for synthesizing Compound I, and pharmaceutically acceptable salts thereof.

Claims22

Dependent claims

1-37. (canceled)

Dependencies are inferred from the claim text.

Facts

Application

18/093,142Filed 4 Jan 2023

Priority

14 Aug 2019

Published

14 Dec 2023

Term ends

Not estimatedThe source records don’t support an estimate.

Classification13 codes

C07D 513/22
Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero…
C07D 207/08
Having no double bonds between ring members or between ring members and non-ring members: with hydrocarbon radicals, substituted by hetero atoms,…
C07D 207/09
With hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms: radicals substituted by nitrogen atoms, not forming part of…
C07D 213/61
With hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals,…:…

Family

Application62/886,660Us provisional application · filed 14 Aug 2019

Application16/992,419Continuation · filed 13 Aug 2020

Application18/093,142Continuation

US 11,584,761 B2Related patent

US 12,122,788 B2Related patent

US 2021/0047345 A1Published application

US 2023/0399343 A1This patent

From the US filing history. Foreign family members aren’t listed.