Heterocyclic amide derivative, preparation method therefor, and application thereof

A compound of formula I or a pharmaceutically acceptable salt, hydrate, solvate, stereoisomer, isotope compound or prodrug thereof;

• wherein,
• R1 is independently selected from the group consisting of:
• H, halogen, substituted or unsubstituted C1-6 alkyl, and substituted or unsubstituted C3-6 cycloalkyl;
• R2 and R3 each is independently selected from the group consisting of:
• H, substituted or unsubstituted C1-6 alkyl, and substituted or unsubstituted C3-6 cycloalkyl;
• or, R2 and R3, together with the C atom to which they are attached, form a C3-6 carbocyclic ring or a 3- to 6-membered heterocyclic ring containing one or two ring members each independently selected from the group consisting of S, O or NRb;
• and the C3-6 carbocyclic ring or 3- to 6-membered heterocyclic ring is optionally substituted with one or more R1;
• Rb each is independently selected from the group consisting of:
• H, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C3-6 cycloalkyl, substituted or unsubstituted C6-10 aryl, substituted or unsubstituted 5- to 6-membered heteroaryl, —C(O)Rc, and —S(O)2Rc;
• Rc each is independently selected from the group consisting of:
• substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C3-6 carbocyclic ring, substituted or unsubstituted 3- to 6-membered heterocyclic ring, substituted or unsubstituted C6-10 aryl, and substituted or unsubstituted 5- to 10-membered heteroaryl;
• R4 and R5 each is independently selected from the group consisting of:
• H, and substituted or unsubstituted C1-3 alkyl;
• or, R4 and R5, together with the C atom to which they are attached, form a substituted or unsubstituted C3-6 carbocyclic ring;
• and
• R6 represents none or is selected from the group consisting of:
• halogen, CN, and haloalkyl;
• unless otherwise specified, the substitution refers to that one or more of the hydrogens in a group is substituted by a substituent selected from the group consisting of:
• halogen, C1-4 alkyl, and C1-4 haloalkyl.